Ransomware Protection (Controlled Folder Access) in Windows Security. Disable it or add RE6.exe and steam.exe to the allowed apps list.
If the Steam client files themselves are corrupted, a quick refresh of the client will fix it without deleting your massive game library. Exit Steam completely. how to fix failed to initialize steam resident evil 6
Steam’s service or registry entries may be broken. how to fix failed to initialize steam resident evil 6