Juq-139 Free Access

The phosphoinositide 3‑kinase (PI3K) pathway is a central regulator of cell growth, metabolism, and survival, and its dysregulation is a hallmark of many malignancies (Miller et al., 2020). Among the class I PI3K isoforms, PI3K‑α (p110α) is frequently mutated (e.g., H1047R) or amplified in breast, colorectal, and endometrial cancers (Samuels et al., 2019). While several PI3K‑α inhibitors have entered clinical trials (e.g., alpelisib), dose‑limiting toxicities and off‑target effects underscore the need for more selective, orally bioavailable scaffolds (Liu & Cheng, 2022).

JUQ‑139, PI3K‑α inhibitor, heterocyclic scaffold, anticancer, structure‑based drug design, kinase selectivity JUQ-139

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