Moreover, physical cartridges are rare. In North America, Rebirth received a limited physical release via Nicalis’s online store. In Europe, a retail version existed but quickly went out of print. As of 2025, a sealed copy can cost $150–300 on eBay.
Playing Isaac on a dual-screen handheld brings some unique advantages, but it also comes with compromises compared to the PC or Switch versions. the binding of isaac rebirth rom 3ds