Ensure that neither your firewall nor your antivirus has quarantined essential game files. You can try adding the game's folder as an exception in your security settings. Further Exploration
If the basic steps don't work, consider these more specific solutions: resident evil 6 fatal error failed open file
Are you seeing a (like a .sngw or .arc file) in your error message? How to FIX Resident Evil 6 All Errors Ensure that neither your firewall nor your antivirus
Find the game's executable in its installation folder. Right-click it, select Properties , and under the Compatibility tab, check Run this program in compatibility mode (try Windows 7 or 8) and Disable fullscreen optimizations Check Firewall/Antivirus: and under the Compatibility tab
Windows’ modern fullscreen optimizations conflict with older DX9 games like RE6.
If all else fails, it’s time for drastic measures.