Regarding version 1.30 of Titan Quest: Immortal Throne, it's likely that you're looking for a No-CD crack to play the game without the original CD. However, I must advise against using cracks or No-CD patches, as they can:

SecuROM worked by verifying the presence of the original game disc in the optical drive. While effective at delaying casual copying, it introduced significant issues for legitimate users, including drive incompatibility, system performance degradation, and the inconvenience of requiring a disc for every play session.

Are you , or are you playing the Anniversary Edition on a modern platform?

Titan Quest: Immortal Throne (v1.30), a "no-CD crack" typically involves replacing the original executable file ( ) with a modified version that removes the disk check. Installation Steps

: Original versions may require specific fixes on modern systems, such as setting OffscreenRenderingMode

Setting up that weren't available in 2007