The E2160 uses . Most LGA 775 boards support faster CPUs, but you must check:

For the most significant performance boost, look for higher-end processors within the same socket family. Note that these may require a BIOS update before installation. Intel Core 2 Quad Q9650 / Q9550

The Intel Pentium E2160 was a $70 chip in 2007. In 2025, you can buy a used for $120 that is 10x faster and uses 6 watts of power.

If you plan to do 4K video editing, heavy gaming, or run Windows 11 (which isn't officially supported). To give you the most accurate advice, could you tell me: What is the model of your motherboard (or the pre-built PC model, like Dell Optiplex)? What is your for this upgrade? What do you primarily use the computer for (web browsing, retro gaming, server)? I can then give you a specific shopping list of parts that will fit your exact machine.