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: Specifically addressed in version 7.2.1.0 to resolve compatibility issues found in the previous 7.2.0.0 release. Enhanced PTZ and Translations

This means your system lacks Visual C++ Redistributables. Download and install from Microsoft: iSpy 7.2.1 Portable Is Here -File- 2019 Download

While an official "portable" build is often discussed on GitHub , users frequently create their own portable versions by unzipping the application files into a single folder. iSpy Connect - INSTAR Wiki : Specifically addressed in version 7